The effect of the microscopic structure of a pore on polymer translocation isstudied using Langevin dynamics simulation, and the consequence of introducingpatterned stickiness inside the pore is investigated. It is found that thetranslocation process is extremely sensitive to the detailed structure of suchpatterns with faster than exponential dependence of translocation times on thestickiness of the pore. The stochastic nature of the translocation processleads to discernable differences between how polymers with different sequencesgo through specifically patterned pores. This notion is utilized to propose astochastic sensing protocol for polynucleotides, and it is demonstrated thatthe method, which would be significantly faster than the existing methods,could be made arbitrarily robust.
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